MIL-OSI Translation: Basis for more robust dental biomaterials

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MIL OSI Translation. Region: Germany / Deutschland –

Source: Charite – Universitatsmedizin Berlin German Research Foundation funds a new research group on materials science in dentistry Artificial and natural boundary zones on a tooth restored with dental biomaterials are different mechanical (left: stresses due to pressure, tension and shear) and biological influences (right: adhesion and penetration of Bacteria, other interactions with biological media). Graphic: Zaslansky / Charité. Joint press release from Charité and TU Berlin Making dental restorations, such as fillings or crowns, more durable – this is what researchers at the Charité – Universitätsmedizin Berlin and the Technical University (TU) Berlin want to achieve by using approaches from materials science and dentistry. The aim is to better understand the composition, structure and stress of the boundary zones between tooth tissue and materials and thus to counteract damage. The interdisciplinary research group “InterDent” is funded by the German Research Foundation (DFG) with 2.1 million euros initially for three years. Artificial biomaterials such as ceramics, metal alloys or plastic-based composites are used to restore – the so-called restoration – of damaged teeth. Such materials must function under repeated, high stresses for many years. For anchoring, close contact with the remaining healthy tooth tissue is necessary through the formation of so-called border zones. These three-dimensional structures, which contain intermediate layers with different compositions, microstructure and properties, are never as durable as their natural counterparts. This is one reason why restorations too often fail prematurely and peel off. The researchers of the new medical and materials science DFG research group FOR2804 “InterDent”, in which the Helmholtz Center Berlin for Materials and Energy (HZB) and the Max Planck Institute for Colloids and Interfaces Research (MPI-KG) in Potsdam are also involved want to understand what causes these weaknesses and thus pave the way to more resistant border zones. “The research group combines four scientific sub-projects and an overarching coordination project, which serve as the basis for a close interaction between materials science and dentistry. Through the interdisciplinary cooperation, the key parameters are to be determined that allow a prediction of possible degradation and can also be transferred to clinical application, ”explains the spokesman for the research group, Dr. Paul Zaslansky, who is the project manager at the Institute for Dentistry, Oral and Maxillofacial Medicine at the Charité. He adds: “Berlin and the surrounding area, where state-of-the-art materials laboratories and an excellent dental environment are close together, offer an ideal breeding ground for inspiring cooperation and new knowledge.” With the aim of creating improved materials for dentistry, the interactions between different materials illuminated with the surrounding tissues. In a sub-project, the prediction of the aging of hard tooth components – the so-called hard tooth substance – is to be made possible in the vicinity of tooth fillings depending on the filling material used. For this purpose, the microstructural and chemical properties of dentin – i.e. dentin – which increasingly change in the course of hardening – known as sclerosis – are examined non-destructively and with high sensitivity and resolution. “In this way, we want to create a model system for dentine sclerosis that will enable us to better understand the changes in structure and element composition,” says Dr. Ioanna Mantouvalou from HZB, who carried out the subproject together with Dr. Zaslansky is in charge. The structure and mechanics of the particularly heavily stressed natural boundary zone between the dentin and the surrounding dental cement in the root area is the focus of another subproject. Although this structure is remarkably robust and fatigue-free, its microstructure and mechanical properties have so far been little studied. “We want to better understand the structure and function of the border zones in different species and types of teeth, root areas and with changes in stress in old age. This enables us to derive general principles that contribute to the long-term fatigue resistance of the cement-dentin boundary and that we can use for bio-inspired approaches to material development, ”says Prof. Dr. Claudia Fleck, Head of the Department of Materials Technology at the TU Berlin and deputy spokesperson for the research group.Bacterial colonization of tooth surfaces as well as the biomaterials that are used for restoration creates a biofilm – a cohesive network of microorganisms in a layer of mucus they form. “Our goal is to scientifically understand the formation and growth of biofilms by specifically researching their composition, microstructure and interfaces with dental materials,” says Dr. Cécile Bidan from the Biomaterials Department at the MPI-KG, who carried out this third sub-project together with Prof. Dr. Sebastian Paris, Scientific Director of the Institute for Dentistry, Oral and Maxillofacial Medicine at the Charité, is in charge. “To do this, we are investigating quantitatively and systematically how biofilms develop spatially and temporally on different surfaces of dental materials.” Another subproject is concerned with how the root canal of the tooth can be sealed against bacteria during restoration. “Using a combination of high-resolution imaging processes, digital image analysis and mechanical test methods, we want to determine parameters that are essential for sealing the boundary zone between biomaterials and tooth roots, and thus lay the foundation for permanent treatment of teeth that have been treated on the root canal”, describes associate professor Dr. Kerstin Bitter from the Department of Preservation and Preventive Dentistry at the Charité started a joint project with Prof. Fleck. In order to overcome the existing shortcomings and limitations of dental biomaterials in the future, a coordinated use of resources and samples as well as an integration of the findings from all sub-projects is necessary . One of the main objectives of the coordination project is therefore to create a culture of collaboration between the disciplines – for the benefit of a better understanding of the border zones and ultimately better dental treatment.

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LinksDepartment for Preservation and Preventive Dentistry at the CharitéMore information about the DFG research group FOR2804 “InterDent”

ContactDr. Paul Zaslansky Institute for Dentistry, Oral and Maxillofacial Medicine Charité – Universitätsmedizin Berlin t: +49 30 450 562 215

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