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Source: Charite – Universitatsmedizin Berlin Berlin Center for Advanced Therapies (BeCAT). Copyright: DGI Bauwerk, visualization: IMAGINA. Visual collaboration. Research Center “The Simulated Human” (Si-M). Copyright: Architect HDR. Image: Imagina Visual Collaboration. Joint press release from Senate Chancellery – Science and Research, Charité and TU Berlin Miniature organs from the 3D printer or living medication – what sounds like a dream of the future should become reality in Berlin Wedding. For this purpose, two research centers are being built next to each other on Seestrasse for almost 68 million euros. In the future, scientists will research biotechnologies and completely new medical approaches here. At the “Berlin Center for Advanced Therapies” (BeCAT), researchers from Charité – Universitätsmedizin Berlin will develop the next generation of drugs. In the future, her colleagues will be working directly opposite researchers from the Technical University of Berlin on modeling human cell and organ functions using technologies such as 3D cultivation, multi-organ chips or 3D bioprinting. For this purpose, the research center “The Simulated Human” (Si-M) is being built with a total of 3,770 square meters of usable space, around a third of which is for laboratories. The further development of human organ models can also make an important contribution to further reducing animal experiments. The completion of the two buildings is planned for 2023. The biotech and medical location in northwest Berlin is becoming increasingly dense. The two new research centers are being built on the newly developed northern part of the Charité Campus Virchow-Klinikum (CVK). In the immediate vicinity, the Charité’s German Heart Center (DHZC) is being built on the south side of the CVK for around 400 million euros, as well as a state-of-the-art laboratory building for life science teaching and research at the Beuth University of Applied Sciences worth 86 million euros. In addition, the Charité is planning a new National Center for Tumor Diseases (NCT) in the immediate vicinity. Michael Müller, Governing Mayor of Berlin and Senator for Science and Research and Chairman of the Charité Supervisory Board, comments: “Berlin Wedding is increasingly becoming a top biotech location. The research centers that are being built here with state and federal funds have the potential to decisively shape the future of medicine. The entire innovation location of Berlin and, above all, patients, of course, benefit from this collaboration between our researchers. ” Axel Radlach Pries, Dean of the Charité: “The research campus Seestrasse is growing and developing dynamically into a top location for medicine and biotechnology in Berlin with a focus on cell-based therapies. The research approach pursued here also makes an important contribution to the development of alternative methods to animal experiments. The scientists who conduct interdisciplinary, translational and joint research here will find the best possible spatial conditions for their projects. The new buildings are designed in such a way that they optimally support the research work, because scientific and architectural components have equally been incorporated into the planning. This is truly state-of-the-art – and we are firmly convinced that the new research campus will make a decisive contribution to medical research at an excellent level. For the State of Berlin and beyond, we want to take health maintenance to a new level. ”“ The scientists at the “The Simulated Human” research center conduct research directly at the interface between biotechnology and medicine and can thus provide completely new impulses. Only the close, interdisciplinary cooperation between the experts from Charité – Universitätsmedizin Berlin and TU Berlin at a common location makes this innovative type of research possible at all. I am convinced that in the end the entire scientific landscape in Berlin will benefit from this, ”says Prof. Dr. Christian Thomsen, President of the Technical University of Berlin. Research on “Simulated Humans” For more than 100 years, medicine has relied on animals as models for the human body to research new drugs and therapies, and has made important advances as a result. Scientists at Si-M have now set themselves the goal of developing new technologies that could make it possible in many areas to replace animal experiments with so-called human model systems. With their help, the complex mechanisms of human health and the development of diseases are to be simulated. To this end, the Charité and Technische Universität Berlin are jointly researching the interface between engineering and medicine and developing new methods and technological approaches. Tissues, organs, cells or cell components can be simulated using innovative methods such as “organ-on-a-chip”, 3D bioprinting or single cell analysis. Research by the “Berlin Center for Advanced Therapies” Up until now, drug development has often been geared towards combating the symptoms of an illness, but not the actual cause. Cell-based novel therapies, also known as “advanced therapies”, cannot be compared with conventional drugs, because it is no longer about synthetic substances to relieve symptoms, but about targeted cell preparations to restore the health of patients. Often referred to as “living medication”, they open up completely new possibilities for the treatment of previously incurable diseases. At BeCAT, Berlin’s expertise in the technology and clinical development of advanced therapies is brought together and brought to an internationally leading level. Si-M and BeCAT are two of currently six research buildings in Berlin that are financed under Article 91b of the Basic Law. The total costs of a total of 34 million euros for the Si-M and 30 million euros for the BeCAT are accordingly borne half by the federal and state governments. With additional funds from the “Special Fund Infrastructure of the Growing City” (SIWANA) program in the amount of 3.8 million euros, basic infrastructures and the connection of the buildings to the Charité Campus Virchow-Klinikum will be built in advance. In a first construction phase, an underground technical building is currently being built, which will connect the two research buildings with one another and will include the electricity, heat and water supply, among other things. Downloads

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ContactMatthias KuderPress Spokesperson for Science and ResearchThe Governing Mayor of Berlin Senate Chancellery – Science and Researcht: +49 30 9026 5010 Manuela ZinglCompany spokeswoman Charité – Universitätsmedizin Berlint: +49 30 450 570 400 Stefanie TerpPress spokeswoman Technical University Berlint: +49 30 314 239 22

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