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MIL OSI Translation. Region: Germany / Deutschland –

Source: Julich Research Center

Jülich, November 16, 2020 – In order to be able to diagnose neurodegenerative diseases such as Alzheimer’s dementia in clinics and research, modern methods of molecular PET imaging (positron emission tomography) are available as biomarkers. These include amyloid PET, which allows pathological amyloid deposits to be made visible in the brain, and ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) -PET, with which glucose metabolism and thus the activity of the brain can be assessed. Both methods provide valuable and additional information for the diagnostic classification.

So far, however, there has been uncertainty about when and in what combination and order these biomarkers should be used optimally. A committee of international experts from various disciplines, with the participation of Forschungszentrum Jülich and the University Hospital Cologne, has now proposed an algorithm for the specific use and the optimal time of the individual biomarkers. This was done on the basis of the knowledge available and taking into account other available biomarkers for the early and differential diagnosis of neurodegenerative diseases. The algorithm names three main diagnostic routes with different biomarker sequences, in which amyloid PET and ¹⁸F-FDG-PET in the order of diagnostic examinations can be placed in different positions, depending on the clinical appearance. Original publication: Gaël Chételat et al .; Amyloid-PET and ⁸F-FDG-PET in the diagnostic investigation of Alzheimer’s disease and other dementias; The Lancet Neurology, Issue 11, Vol 19, 01 November 2020, DOI: https://doi.org/10.1016/S1474-4422(20)30314-8 Further information: Institute of Neuroscience and Medicine, Molecular Organization of the Brain (INM- 2) Contact person: Prof. Alexander DrzezgaInstitute for Neuroscience and Medicine, Molecular Organization of the Brain (INM-2) Tel .: 02461 61-4898E-Mail: a.drzezga@fz-juelich.dePress contact: Annette Stettien Corporate CommunicationsTel .: 02461 61-2388E-Mail: a.stettien @ fz-juelich.de

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EDITOR’S NOTE: This article is a translation. Apologies should the grammar and / or sentence structure not be perfect.

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