Source: United Kingdom – Executive Government & Departments
A study published in Nature Immunology compares antibody responses to SARS-CoV-2 in children and adults.
Prof Eleanor Riley, Professor of Immunology and Infectious Disease, University of Edinburgh, said:
“This high quality, peer-reviewed study compares the antibody response to SARS-CoV-2 spike (S) and nucleocapsid (N) in children and adults with either mild/asymptomatic or severe disease. Adults tended to have higher antibody and more diverse antibody responses than children, with the highest responses seen in adults with severe disease. Children did not make significant amounts of antibody against the N protein and also made very little in the way of IgA antibodies (that are secreted into the nose and throat and may protect against reinfection).
“ Whilst there are a number of potential explanations for these data, including underlying differences in the immune systems of children and adults, one likely explanation is the viral load in these different groups of patients. Adults tend to have higher viral loads than children and adults with severe disease have particularly high viral loads. The higher the viral load, the stronger the stimulus for the immune response and thus the more antibody is produced and the more diverse the types of antibodies produced.
“These data do not explain why some children develop MIS-C. Studies of cellar immune responses may throw more light on this very rare but serious condition.”
‘Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum’ by Weisberg et al is published in Nature Immunology.
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Prof Eleanor Riley: “No COIs to declare.”